Facile Microwave Synthesis of Pd-Catalyzed Suzuki Reaction for Bis-6-Aryl Imidazo[1,2-<i>a</i>]Pyridine-2-Carboxamide Derivatives with PEG3 Linker

An efficient and facile synthetic procedure has been developed for the synthesis of novel series Bis-6-aryl-imidazo[1,2-a]pyridine-2-carboxamide containing 3,3'-((oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine) derivatives (6a-6j). application Palladium catalyzed Suzuki reaction on amine-(CH2)3-PEG3-(CH2)3-amine linked 6-bromo imidazo[1,2-a]pyridine-2-carboxamide was reported their products are discussed. The optimized through numerous catalytic conditions this strategy, it fixed with best approach having advantages less time, higher degree yield, most consumption starting material, selection catalyst success reaction. ideal spectroscopic characterization (PMR, CMR, IR MS) have utilized finalization synthesized adducts.